Download Ciba Foundation Symposium High Altitude Physiology Cardiac And Respiratory Aspects
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Asian Pacific Journal of Allergy and Immunology. Current drug targets. International Journal of Clinical and Laboratory Research. Medical immunology [electronic resource] [Med Immunol]. Ocular immunology and inflammation [Ocul Immunol Inflamm]. J Appl Physiol ; — 8. Hemoglobin concen- endogenous and exogenous EPO. Altitude-induced tration of high-altitude Tibetans and Bolivian Aymara. Am J Physiol hypoxia is associated with reduced EPO requirements in a Anthropol ; — subset of patients on hemodialysis who had treatment- 9. Adaptations to altitude: a current assessment. Annu Rev refractory anemia .
Hypoxia is also believed to affect Anthropol ; — the dose—response relationship of EPO. A large retrospec- The study also noted that resistance to EPO Minimal hypoxic pulmonary decreased with increasing elevation . J Appl Physiol ; — Penaloza D, Arias-Stella J.
The heart and pulmonary circulation at Summary high altitudes: healthy highlanders and chronic mountain sickness. Circulation ; — Nitric oxide and cardiopulmonary hemodynamics in Tibetan that should be of interest to nephrologists. Living chroni- highlanders.
J Appl Physiol ; — cally under hypoxic conditions can be associated with Some function of hemoglobin that utilizes nitrite as a substrate. Nitric oxide during altitude of the Himalayas.
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However, the Andean population is par- acclimatization. N Engl J Med ; — Response of ticularly susceptible to the deleterious effects of chronic skeletal muscle mitochondria to hypoxia. Genetic adaptation to mental exposure to cobalt from the local mines. Nature ; — and coronary heart disease, which might relate to both the Vav3 mediates receptor protein tyro- effects of high altitude and differences in diet. However, sine kinase signaling, regulates GTPase activity, modulates cell mor- the dark side of high altitude is the increased frequency of phology, and induces cell transformation.
High Altitude, Haematocrit and Age | Nature
Further studies examining the Semenza GL. HIF mediator of physiological and pathophysiolo- mechanisms driving HARS may help our understanding gical responses to hypoxia. Natural selection on EPAS1 of not only its cause, but may provide insights into the HIF2alpha associated with low hemoglobin concentration in renal adaptive and maladaptive responses to a hypoxic Tibetan highlanders.
Genetic evidence for high- Acknowledgements. We thank the Maren Foundation for the support of altitude adaptation in Tibet. Science ; 72—75 this manuscript. Sequencing of 50 human exomes reveals adaptation to high altitude. None declared. A genome-wide search for signals of high altitude adaptation in Tibetans. Mol Biol Evol ; — References Identifying signatures of natural selection in Tibetan and Andean populations using dense 1. Moore LG. Human genetic adaptation to high altitude.
High Alt genomes scan data. Genetic association 2. Andean, Tibetan, and Ethiopian patterns of adaptation to analysis of chronic mountain sickness in an Andean high-altitude high-altitude hypoxia.
Integr Comp Biol ; 18—24 population. Identifying positive selection can- Cardiac function, microvascular didate loci for high-altitude adaptation in Andean population. Hum structure, and capillary hematocrit in hearts of polycythemic rats. Naeije R.
High altitude physiology cardiac and respiratory aspects
Physiological adaptation of the cardiovascular system to Chronic kidney disease at high altitude. Prog Cardiovasc Dis ; — high altitude. J Am Soc Nephrol ; — Moret PR.
High altitude renal syn- at high altitude. In: Porter R, Knight J eds. Renal function in man posium. London: Churchill Livingstone, , pp. J Appl Physiol ; 79—80 Lozano R, Monge C. J Appl Physiol ; triphosphate signature of metabolic defense against hypobaric — hypoxia. Myocardial xanthine Biochim Biophys Acta ; — binding by hemoglobin and on organic phosphate levels.
J Clin Uric acid predicts clinical outcomes in heart Invest ; — failure: insights regarding the role of xanthine oxidase and uric acid Ruiz L, Penaloza D. Altitude and hypertension.
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Epidemiology of hypertension on the Tibetan Plateau. Hum uric acid in hypertension and cardiovascular and renal disease? Biol ; — Hypertension ; — Prevalence, awareness, treatment, and Hyperuricaemia in polycythaemia control of hypertension among herdsmen living at 4, m in Tibet. Hyperuricemia, hyper- Prevalence and risk factors of tension, and proteinuria associated with high-altitude polycythemia.
Mild hyperuri- Hurtado A. Animals in high altitude: resident man. In: Handbook of cemia induces glomerular hypertension in normal rats. Urinary protein excretion Reduction in in high-altitude residents. J Appl Physiol ; — mortality from coronary heart disease in men residing at high Naeye RL. Children at high altitude: pulmonary and renal abnormal- altitude. N Engl J Med ; — ities.
Circ Res ; 33—38 Residence in mountai- Glomeruli and blood nous compared with lowland areas in relation to total and coronary pressure. Less of one, more the other? Am J Hypertens ; 1: mortality. A study in rural Greece. J Epidemiol Community Health — ; — Hyperuricemia causes glo- Am J Nephrol ; 2—7 Lower mortality from coronary heart disease and stroke at higher Hyperuricemia induces a altitudes in Switzerland.
Circulation ; — primary renal arteriolopathy in rats by a blood pressure-independent Altitude, life expectancy mechanism. Erythropoietin cancers: national population-based analysis of US counties. J Epide- response to hypoxia in patients with diabetic autonomic neuropathy miol Community Health ; e17 and non-diabetic chronic renal failure.
Diabet Med ; 65—69 Hypoxic preconditioning triggers The effect of altitude myocardial angiogenesis: a novel approach to enhance contractile change on anemia treatment response in hemodialysis patients.